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Transfusion-associated graft versus host disease
Timing: within 4 to 21 days of transfxn Risk: immunocompromised, especially with B-cell mediated malignancies, ALL, Hodgkin lymphoma, patients receiving immunosuppressive regimens, congenital immunodef syndromes, transfusion from relatives (partial HLA matching) Pathophys: donor lymphocytes proliferate and attack host (severe compromise of host ...
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