According to the Centers for Disease Control and Prevention, 1,267 cases of measles had been confirmed in the U.S. as of July 1, 2025, including cases in Palmetto State neighbors Georgia and North Carolina along with 35 other states. The CDC has confirmed three measles deaths so far this year.

The South Carolina Department of Public Health has confirmed a case of measles in an Upstate resident, marking the first confirmed case in the state since September 2024.