eLife2d
Genetic inactivation of zinc transporter SLC39A5 improves liver function and hyperglycemia in obesogenic settings
This fundamental study substantially advances our understanding of the role of zinc in metabolism, specifically a newly established clinical link between mutations in the zinc transporter SLC39A5, ...
eLife2d
Structure of the human CTF18 clamp loader bound to PCNA
Briola and co-authors determined the structure of the human CTF18 clamp loader bound to PCNA to high resolution, analyzed the structure, and tested a new mechanism involving a human-specific Ctf18 ...
eLife3d
Imaging of brain electric field networks
We present a method for direct imaging of the electric field networks in the human brain from electroencephalography (EEG) data with much higher temporal and spatial resolution than functional MRI ...
eLife3d
UBR-1 deficiency leads to ivermectin resistance in C. elegans
This important study will allow for a better understanding of anthelmintic drug resistance in nematodes, a growing concern for public health. The authors provide a detailed analysis of the role of UBR ...
eLife3d
Deep learning linking mechanistic models to single-cell transcriptomics data reveals transcriptional bursting in response to DNA damage
The input of the DeepTXsolver is the parameters of the mechanism model, and the output is the corresponding stationary distribution solution of the model. The input to the DeepTXinferrer is the ...
eLife3d
An evolutionarily conserved Hox-Gbx segmentation code in the rice coral Montipora capitata
The authors studied the development of mesentery borders in the rice coral Montipora, a new experimental system, to complement existing data from the sea anemone Nematostella. They make a solid case ...
eLife3d
Prefrontal working memory signal primarily controls phase-coded information within extrastriate cortex
This study uses electrophysiological recordings, causal manipulations of activity, and modeling to investigate how the maintenance of a spatial location in working memory affects the representation of ...
eLife3d
Correlated spontaneous activity sets up multi-sensory integration in the developing higher-order cortex
This valuable study combines experiments and theory to investigate the putative role of spontaneous correlated activity in establishing aligned topographic maps of neural activity in higher-order ...
eLife3d
Social Experience Shapes Fighting Strategies for Reproductive Success
The paper presents a new behavioral assay for Drosophila aggression and demonstrates that social experience influences fighting strategies, with group-housed males favoring high-intensity but ...
eLife3d
Experience shapes the transformation of olfactory representations along the cortico-hippocampal pathway
This potentially important study describes the progressive transformation of olfactory information across five different brain regions in the olfactory pathway. While the dataset could be of broad ...
eLife4d
Rab10 inactivation promotes AMPAR insertion and spine enlargement during long-term potentiation
Among these sensors, we further focused on the spatiotemporal dynamics of Rab10 and Rab4 activity during sLTP. We found that postsynaptic stimulation leads to the persistent inactivation of Rab10 and ...
eLife4d
Emergence of power-law distributions in protein-protein interaction networks through study bias
Degree distributions in protein-protein interaction (PPI) networks are believed to follow a power law (PL). However, technical and study bias affect the experimental procedures for detecting PPIs. For ...