eLife11h
Mistargeted retinal axons form synaptically segregated subcircuits in the visual thalamus of albino mice
Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, USA ...
eLife13h
Endophilin A1 facilitates organization of the GABAergic postsynaptic machinery to maintain excitation-inhibition balance
This study presents a valuable finding on the molecular mechanisms that govern GABAergic inhibitory synapse function. The authors propose that Endophilin A1 serves as a novel regulator of GABAergic ...
eLife12h
Computational method pinpoints how cause-and-effect relationships ebb and flow over time
A new computer model can more accurately assess how causal relationships in complex real-world systems vary over time.
eLife2d
Targeting IRE1α improves insulin sensitivity and thermogenesis and suppresses metabolically active adipose tissue macrophages in obesity
Department of Physiology, Harold Hamm Diabetes Center, The University of Oklahoma Health Science Center, Oklahoma City, United States ...
eLife2d
Transcriptional pattern enriched for synaptic signaling is associated with shorter survival of patients with high-grade serous ovarian cancer
Penn Ovarian Cancer Research Center and Basser Center for BRCA, University of Pennsylvania, Perelman School of Medicine, Philadelphia, United States ...
eLife2d
PointTree: Automatic and accurate reconstruction of long-range axonal projections of single-neuron
This important paper takes a novel approach to the problem of automatically reconstructing long-range axonal projections from stacks of images. The key innovation is to separate the identification of ...
eLife1d
DendroTweaks: An interactive approach for unraveling dendritic dynamics
This manuscript introduces DendroTweaks, a useful web application and Python library that, compared to existing modeling tools, eases interactive graphical exploration, development, and validation of ...
eLife1d
Gut Microbes: Regulating uric acid
Certain strains of a bacterium found in the gut of some animals, Lactobacillus plantarum, are able to counter hyperuricemia, a condition caused by high levels of uric acid in the blood.
eLife4d
An ancient competition for the conserved branchpoint sequence influences physiological and evolutionary outcomes in splicing
This important manuscript provides insights into the competition between Splicing Factor 1 (SF1) and Quaking (QKI) for binding at the ACUAA branch point sequence in a model intron, regulating exon ...
eLife6d
A SMARTR workflow for multi-ensemble atlas mapping and brain-wide network analysis
This study describes a new analysis strategy to compare active neurons during behavioral tasks across the brain. This is significant because analysing how different brain areas are active during ...
eLife4d
Molecular characterization of gustatory second-order neurons reveals integrative mechanisms of gustatory and metabolic information
This study presents valuable insights into the organization of second-order circuits for gustatory neurons, particularly how they integrate opposing taste inputs and the metabolic states that regulate ...
eLife7d
No effect of additional education on long-term brain structure – a preregistered natural experiment in thousands of individuals
A regression discontinuity analysis finds essentially no effect of 1 additional year of secondary education on brain structure in adulthood. This is a valuable finding that adds to the literature on ...