The San Francisco 49ers have been decimated by injuries all year, specifically at the running back position. Christian ...

Isaac Guerendo was initially uncertain for Thursday night, but the rookie looks like he might give it a go. Here's the latest ...

Getting hurt the Sunday before a Thursday night game gave San Francisco 49ers fans plenty of reason to be skeptical about ...

Most starters were on the sideline late in Week 14's lopsided win, while only one D-lineman played over 30 snaps.

The San Francisco 49ers running back spot has been a position of focus for fantasy football players throughout the season, ...

The 49ers won’t be down to their 4th-string running back tonight against the Rams as Isaac Guerendo is expected to play ...

PM ET game airing live on Amazon Prime Video, bookmakers have posted player props for Isaac Guerendo. NFC West rivals play in ...

Rookie running back Isaac Guerendo is not participating in Tuesday's practice session with the San Francisco 49ers. Guerendo ...

San Francisco 49ers rookie running back Isaac Guerendo sustained a foot injury and is questionable to return in Sunday's ...

The 49ers are playing on "Thursday Night Football" against the Rams. Will running back Isaac Guerendo be ready to play after ...

According to ESPN's Adam Schefter, San Francisco 49ers rookie running back Isaac Guerendo is expected to suit up for Thursday ...

“49ers rookie RB Isaac Guerendo plans to play Thursday night vs. the Rams despite his sprained foot that has left him being ...