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Abstract: Optimization of the enzyme turnover rate kcat in enzyme-constrained metabolic models, such as S. cerevisiae’s ecYeastGEM, is essential to improve the accuracy of cellular metabolism ...
Abstract: In this study, we proposed a new method combining graph sampling aggregation network (GraphSAGE), Contrastive Learning (CL) and Bayesian Optimization. First, GraphSAGE was used to model the ...