Osteoclasts, bone-degrading cells, operate under the control of osteoblasts, bone-forming cells. But recent studies have suggested that osteoclasts don't just passively carry out orders—they in ...

Both osteoblasts and osteoclasts are necessary for fracture repair. While osteoblasts are known to control the formation and activity of osteoclasts, the inter-cellular signaling involved in this ...

A mouse study shows that dietary oleic acid, a key Mediterranean diet component, protects against age-related bone and ...

Remodeling involves both osteoclasts and osteoblasts, which form the basic multicellular unit. 20 Since osteoblasts are known to differentiate from mesenchymal precursors in the bone marrow, 3 the ...

In a study published recently in Communications Biology, researchers led by Kanazawa University explain how a tiny fish could help end painful metabolic and genetic bone diseases.

Further experiments in a co-culture system with osteoblasts and osteoclasts confirmed iSN40's dual action. The results ...

Panel A shows osteoclasts and osteoblasts in normal bone (toluidine blue, ×100). The large osteoclast is actively resorbing bone. Osteoblasts are small, cuboid cells that actively lay down bone ...

Osteoblasts act in a group to make bone over the course of several months. ... Using this method, they explored the interplay between bone-destroying osteoclasts and bone-forming osteoblasts.

Osteoblasts then play a role in the formation of new bone tissue. Multiple myeloma can upset the balance of this process. Multiple myeloma cells produce osteoclast-activating factors.

As an endogenous osteogenic peptide with the capacity to regulate osteoblast-osteoclast coupling in health and disease, PEPITEM offers the real possibility for maintenance or restoration of bone ...