Menopause, marking the end of a woman's reproductive cycle, often arrives earlier for Indian women due to nutritional ...

Reducing circulating estrogen levels increases osteoclast activity and, therefore, bone loss. 9 Not only is the balance of osteoblasts and osteoclasts altered, but the microenvironment of the ...

A transformative study has uncovered the pivotal role of the protein Naked cuticle homolog 2 (NKD2) in regulating the ...

To identify novel bone remodeling factors and related mechanisms involved in both osteoclast and osteoblast differentiation, a team of researchers led by Professor Tomoki Nakashima from the ...

Figure 3. Therapeutic targeting of RANKL/OPG/RANK signaling. Osteoclasts express RANK, while osteoblasts express the RANKL and also secrete a decoy receptor and physiological inhibitor of the ...

Osteoclasts which break down and remove old bone. Osteoblasts which build new bone. Our bones stop growing in length by the time we are about 18 years old, but they may continue to grow into our early ...

Although, bone remodeling by osteoblasts and osteoclasts is crucial for maintaining skeletal health, PTH-induced osteoclast differentiation can decrease treatment efficacy in patients with ...

Osteoblasts and osteoclasts are two types of cells that play critical roles in bone tissue maintenance and remodelling. Osteoblasts are bone-forming cells that synthesise and deposit new bone ...

As an endogenous osteogenic peptide with the capacity to regulate osteoblast-osteoclast coupling in health and disease, PEPITEM offers the real possibility for maintenance or restoration of bone ...

A comprehensive review focusing on the role of osteoclasts as active regulators of bone homeostasis by influencing osteoblast function explores the currently known mechanisms and coupling factors ...

A new research paper was published in Aging, entitled, “Chlorogenic acid prevents ovariectomized-induced bone loss by facilitating osteoblast functions and suppressing osteoclast formation.” ...

Messages sent by osteoblasts to osteoclasts are enclosed in an extracellular vesicle. Jul 14, 2020. Study identifies protein responsible for mechanism behind bone loss. Aug 8, 2019.