When Conan O'Brien emerged onto the stage at the 2025 Oscars for his opening monologue, he did so in a rather unusual way: by crawling out of Demi Moore's spine in a morbid homage to Best Picture nominee The Substance.

Karla Sofía Gascón has entered the Dolby Theatre — and Conan O’Brien couldn’t wait to crack a joke at her expense. Despite the recent controversy, the “Emilia Pérez” star, 52, attended the Academy Awards 2025 on Sunday, March 2, in Los Angeles.

Conan O’Brien debuted on the Oscars stage with his signature self deprecation, jabs about Netflix price increases, and the three-and-a-half hour run time of “The Brutalist.” “I didn’t want it to end—and luckily it didn’t,