eLife3d
An evolutionarily conserved Hox-Gbx segmentation code in the rice coral Montipora capitata
The authors studied the development of mesentery borders in the rice coral Montipora, a new experimental system, to complement existing data from the sea anemone Nematostella. They make a solid case ...
eLife3d
Progressive neural engagement within the IFG-pMTG circuit as gesture and speech entropy and MI advances
In this study, employing information-theoretic metrics, we quantified gesture and speech information, alongside their interaction, utilizing entropy and mutual information (MI). Neural activities were ...
eLife3d
Genomic and structural insights into Jyvaskylavirus, the first giant virus isolated from Finland
Universidade Federal de Minas Gerais, Institute of Biological Sciences, Department of Microbiology, Belo Horizonte, Brazil ...
eLife3d
UBR-1 deficiency leads to ivermectin resistance in C. elegans
This important study will allow for a better understanding of anthelmintic drug resistance in nematodes, a growing concern for public health. The authors provide a detailed analysis of the role of UBR ...
eLife3d
Prefrontal working memory signal primarily controls phase-coded information within extrastriate cortex
This study uses electrophysiological recordings, causal manipulations of activity, and modeling to investigate how the maintenance of a spatial location in working memory affects the representation of ...
eLife3d
Autologous P63+ lung progenitor cell transplantation in idiopathic pulmonary fibrosis: a phase 1 clinical trial
This important study describes a first-in-human trial of autologous p63+ stem cells in patients with idiopathic pulmonary fibrosis, a lethal condition for which effective treatments are lacking. The ...
eLife3d
Load-based divergence in the dynamic allostery of two TCRs recognizing the same pMHC
Increasing evidence suggests that mechanical load on the αβ T cell receptor (TCR) is crucial for recognizing the antigenic peptide-loaded major histocompatibility complex (pMHC) molecule. Our recent ...
eLife3d
Correlated spontaneous activity sets up multi-sensory integration in the developing higher-order cortex
This valuable study combines experiments and theory to investigate the putative role of spontaneous correlated activity in establishing aligned topographic maps of neural activity in higher-order ...
eLife4d
Lung Development: Exploring a complex constellation of signaling pathways
Cells called alveolar myofibroblasts, which have a central role in the development of the lung after birth, receive an orchestrated input from a range of different signaling pathways.
eLife2d
Genetic inactivation of zinc transporter SLC39A5 improves liver function and hyperglycemia in obesogenic settings
This fundamental study substantially advances our understanding of the role of zinc in metabolism, specifically a newly established clinical link between mutations in the zinc transporter SLC39A5, ...
eLife3d
Deep learning linking mechanistic models to single-cell transcriptomics data reveals transcriptional bursting in response to DNA damage
The input of the DeepTXsolver is the parameters of the mechanism model, and the output is the corresponding stationary distribution solution of the model. The input to the DeepTXinferrer is the ...
eLife2d
Structure of the human CTF18 clamp loader bound to PCNA
Briola and co-authors determined the structure of the human CTF18 clamp loader bound to PCNA to high resolution, analyzed the structure, and tested a new mechanism involving a human-specific Ctf18 ...