Then they inserted a few RNA bases into strings of DNA that are necessary for the enzymes’ function, forcing the DNA polymerases to develop reverse transcriptase skills.

Reverse transcriptase is responsible for converting viral RNA into DNA via its dual functions – the DNA polymerase and RNase H activities – making it an attractive and multifaceted target.

In Split Prime Editing (Split-PE), reverse transcriptases and nCas9 components of prime editing proteins function efficiently when separate.

Nonnucleoside reverse transcriptase inhibitors (NNRTIs) comprise approximately 10% of the HIV drug market worldwide, and efavirenz leads this class with $680 million annual sales in the United ...

Defense-associated reverse transcriptase (DRT) systems provide an intriguing counterpoint to this immune strategy by instead leveraging DNA synthesis, but the identities and functions of their DNA ...

Use of nucleoside reverse transcriptase inhibitors (NRTIs) is associated with a significantly lower risk of developing Alzheimer disease (AD), according to findings published in Alzheimer’s & Dementia ...

Recently, the research team led by Min Wang at the College of Marine Life Sciences, Ocean University of China, published a study titled " Diversity of reverse-transcriptase-containing viruses ...

“Our research suggests that polymerase theta’s main function is to act as a reverse transcriptase,” says Pomerantz. “In healthy cells, the purpose of this molecule may be toward RNA ...

Alzheimer's disease is the most common cause of dementia and affects more than a tenth of Americans aged 65 and older.

The crystal structure of a human endogenous reverse transcriptase has similarities to HIV reverse transcriptase, a well-known tractable drug target, which will help design drugs to treat cancer ...

The crystal structure of a human endogenous reverse transcriptase has similarities to HIV reverse transcriptase, a well-known tractable drug target, which will help design drugs to treat cancer ...