When a protein folds, its string of amino acids wiggles and jiggles through countless conformations before it forms a fully folded, functional protein. This rapid and complex process is hard to ...

Proteins are among the most studied molecules in biology, yet new research shows they can still hold surprising secrets. Researchers have discovered previously undetected chemical bonds within ...

When Schrödinger launched more than 30 years ago, computational biology was a nascent technology. Schrödinger, a pioneer in the field, relied heavily on the Protein Data Bank (PDB), a collection of ...

Structural reconstruction of thousands of ancient nitrogenases through Earth’s history uncovers architectural constraints that shaped their evolution under global environmental transitions.

Imagine standing on a vast, dark plain. Without light, you cannot see dips and rolls in the grass or make out hills and valleys. Even if there’s a city off in the distance to your right, it does ...

What they saw The Seegar Lab used advanced cryogenic electron microscopy techniques to visualize the structure of the ADAM17 enzyme bound to its regulator protein, iRhom2, and identify key elements ...

Every protein in the body is encased in a water shell that directs protein structure, provides vital stability and steers function. Because of this, water molecules represent a powerful but largely ...

Google DeepMind's groundbreaking new AI predicts not only the structure of proteins, ligands, DNA, RNA and "all of life's molecules," but how they'll interact. It promises a radical, revolutionary ...

Drug developers have historically glued their attention to targeting the precise and fine-tuned protein structures underlying biological function. Yet this approach misses over 50% of the human ...