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Yes, you can use a USB mouse on Nintendo Switch 2, as demonstrated by a Koei Tecmo producer

Nintendo Switch 2 supports traditional USB mouse controls This was revealed in a presentation for Nobunaga's Ambition: Awakening Complete Edition It opens up the possibilities for wider mouse and ...
Gameranx

Nintendo Confirms Switch 2 Can Use USB Keyboards On Their Website – Perfect To Pair With Mouse Mode?

There’s so many Switch games that could have used mouse and keyboard support but didn’t have them. Nintendo seems to have discreetly confirmed a feature on the Switch 2, but as usual, this doesn’t ...