Complement molecules are the immune proteins responsible for identifying bacteria, viruses, and other foreign invaders as they circulate through our bodies. Their function helps lymphocytes to locate ...

We are studying the role of the complement system in kidneys and brains during health and disease. Traditionally, major complement proteins were shown to be generated by the liver and are functional ...

Variants in complement system genes alter an individual's risk of developing AMD. Recent studies have shown how some risk-associated genetic variants alter the function of the complement system.

Michael M. Frank, Keith Joiner, Carl Hammer, The Function of Antibody and Complement in the Lysis of Bacteria, Reviews of Infectious Diseases, Vol. 9, Supplement 5. Perspectives on Bacterial ...

Among the most significant genetic risk factors for age-related macular degeneration is the Y402H variant of complement factor H, which, along with its splice isoform FHL-1, impairs binding to the ...

“Nipocalimab appears to have an effect on lowering but not completely suppressing complement activation, and may thus potentially reduce NMJ damage, while still allowing the complement pathway ...

Gemini Therapeutics Announces FDA Fast Track Designation Granted for GEM103 for the Treatment of Dry Age-Related Macular Degeneration (AMD) in Patients With Complement Factor H (CFH) Loss of ...