Figure 1: Dynamic ligand binding dictates partial agonism: model, predictions and chemical tools. Our findings revise the concept of partial agonism at GPCRs. We show that bipharmacophoric ligands ...

Researchers report that a single-stranded DNA-binding protein, once thought to be a static player among the many molecules that interact with DNA, actually moves back and forth along single-stranded ...

The clinical need for ultrasensitive molecular analysis has motivated the development of several endpoint-assay technologies capable of single-molecule readout. These endpoint assays are now primarily ...