After an encouraging performance in Week 1, the Rams (0-2) got something of a wake-up call in the 41-10 loss to the Cardinals. Kyler Murray escaped every sack attempt. James Conner broke seemingly every tackle in the run game.

The Rams are 0-2 and have allowed the most yards in the NFL, but Sean McVay isn’t ready to make big changes on defense

Kupp has racked up 18 catches for 147 yards and one touchdown through two games this season, leaving early in the second contest. Kupp is one of the main engines that makes the Rams offense click so losing him for any extended amount of time is a detriment to their playoff chances.

The Rams have their work cut out for them in Week 3 but they have a chance to upset the 49ers if they win these 5 matchups

Although the famed Rams-49ers rivalry has been decidedly tilted in San Francisco’s direction in recent years, the games have still been must-see spectacles.

If Kittle does miss Sunday's game, he will join star running back Christian McCaffrey, who is currently on the Injured Reserve list with a calf injury and Achilles tendonitis. Wide receiver Deebo Samuel is also missing time following a calf injury he suffered in Week 2. Quarterback Brock Purdy is running low on targets to throw to.