Of course, Wyle is no stranger to garnering awards buzz, having earned 5 noms for Outstanding Supporting Actor in a Drama for his excellent work as up-and-coming surgeon Dr. John Carter on ER. On his newest series,

Ifeachor hinted at her exit last week when she shared an Instagram post bidding farewell to her character, Dr. Collins

In a statement shared with PEOPLE, Wyle, 54, said of the nominations, including one for outstanding lead actor in a drama series, "I’m humbled and grateful"

The actress who portrayed Dr. Collins in Season 1 announced last week that she would not be returning to the HBO Max drama but said “what a blessing” to participate. She called it an “absolute privilege to play Dr. Heather Collins in such a groundbreaking season and piece.”

The Pitt star and producer Noah Wyle responds to Tracy Ifeachor's departure.

Noah Wyle and Katherine LaNasa celebrated their Emmy nominations together from "The Pitt" set while filming Season 2.

While touting The Pitt‘s 13 nominations on Tuesday, Noah Wyle gave a hint about what to expect in season 2 of the HBO Max medical drama. In April, executive producer R. Scott Gemmill, EP John Wells and EP/star Wyle appeared at Deadline’s Contenders TV in April and shared that the next 15 hours of The Pitt will take place over

The Pitt star Noah Wyle has weighed in on the departure of co-star Tracy Ifeachor, who played Dr. Heather Collins on the hit HBO Max medical drama. At such a critical moment in US history, we need reporters on the ground. Your donation allows us to keep sending journalists to speak to both sides of the story.

The star of "The Pitt" will compete in the Outstanding Lead Actor in a Drama Series category for the first time. He was last nominated in 1999 for "ER"

Noah Wyle broke his silence on his The Pitt costar — and onscreen love interest — Tracy Ifeachor’s surprising exit ahead of season 2. “Truthfully, we loved the actress,” Wyle, 54, told Deadline on Tuesday,

The hospital that inspired "The Pitt" has the longest wait times in the city, though long visits are common across the major health systems.