Phase II Study of Afatinib in Patients With Tumors With Human Epidermal Growth Factor Receptor 2–Activating Mutations: Results From the National Cancer Institute–Molecular Analysis for Therapy Choice ...
More typically, a sequential subgroup-specific approach allocates the entire significance level α to first test the biomarker-positive subgroup. This is appropriate because one believes it is unlikely ...
Under mild Markov assumptions, sufficient conditions for strict minimax optimality of sequential tests for multiple hypotheses under distributional uncertainty are derived. First, the design of ...
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