Estrogen plays an important role in keeping bones healthy. Now, researchers investigated how membrane-initiated estrogen ...

Osteoclasts, bone-degrading cells, operate under the control of osteoblasts, bone-forming cells. But recent studies have suggested that osteoclasts don't just passively carry out orders—they in ...

Both osteoblasts and osteoclasts are necessary for fracture repair. While osteoblasts are known to control the formation and activity of osteoclasts, the inter-cellular signaling involved in this ...

Remodeling involves both osteoclasts and osteoblasts, which form the basic multicellular unit. 20 Since osteoblasts are known to differentiate from mesenchymal precursors in the bone marrow, 3 the ...

During this "remodeling" process, osteoclasts remove mineralized bones, whereas osteoblasts form new bones. These resorption and formation phases are linked and balanced with intermittent coupling ...

Panel A shows osteoclasts and osteoblasts in normal bone (toluidine blue, ×100). The large osteoclast is actively resorbing bone. Osteoblasts are small, cuboid cells that actively lay down bone ...

Further experiments in a co-culture system with osteoblasts and osteoclasts confirmed iSN40's dual action. The results indicated that while promoting osteoblast activity and bone formation, ...

Osteoblasts and osteoclasts are two types of cells crucial for the maintenance and remodeling of bone tissue. While osteoblasts are the bone-forming cells responsible for synthesizing and ...

As an endogenous osteogenic peptide with the capacity to regulate osteoblast-osteoclast coupling in health and disease, PEPITEM offers the real possibility for maintenance or restoration of bone ...

In a study published recently in Communications Biology, researchers led by Kanazawa University explain how a tiny fish could help end painful metabolic and genetic bone diseases.