A new computational model of the brain based closely on its biology and physiology has not only learned a simple visual ...

A biologically grounded computational model built to mimic real neural circuits, not trained on animal data, learned a visual categorization task just as actual lab animals do, matching their accuracy ...

Researchers have used microRNA-based direct reprogramming to generate neurons from fibroblasts, providing new insights into late-onset Alzheimer’s disease. Aging is the most significant risk factor ...

The use of iPSC-derived neurons to model human diseases like Alzheimer’s has enabled new advances. Nonetheless, a limitation of these cells is that their reprogramming resets epigenetic marks, erasing ...

The spread of tau protein aggregates in the brain—a process that drives cognitive decline in Alzheimer’s disease and frontotemporal dementia—has been studied with a model that incorporates human ...

The new model developed by Flatiron Institute researchers proposes that biological neurons have more control over their surroundings than previously thought, something that could be replicated in the ...

New research provides a potential brain-based explanation for social touch aversion in some forms of autism. A study published in Nature Communications finds that in a mouse model of Fragile X ...

Neuronal death is the indisputable endgame of Alzheimer’s disease, but what does the killing, and how? To try to solve the mystery, researchers have staged increasingly complex crime scenes in ...