Based upon the findings of the SHEP and Syst-Eur trials, the only randomized controlled trials that used morbidity and mortality data as main outcome measures available to date on ISH in the ...
Three major outcome trials of ISH were conducted in the United States, Europe, and China ( Table I). Two large clinical trials, the Systolic Hypertension in the Elderly Program (SHEP) [7] and the ...
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