The comparison of related genomes has emerged as a powerful lens for genome interpretation. Here we report the sequencing and comparative analysis of 29 eutherian genomes. We confirm that at least 5.5 ...
An analysis of 360 breast-cancer genomes has identified cancer-driving mutations in 9 non-coding DNA sequences called promoters, which regulate gene expression. The result hints at the prevalence of ...
When regions of the human genome where the DNA can fold into unusual three-dimensional structures called G-quadruplexes (G4s) are located in regulatory sequences or other functional, but non-protein ...