With its proxy Hezbollah decimated, resupply routes though Syria lost, and the prospect of US President Donald Trump's reversion to a "maximum pressure" policy anticipated next year, Iran's fortunes face an irreversible decline.

The loss of the route through Syria is a blow to the Lebanese militia and its most important ally, Tehran.

Iranian Foreign Minister Abbas Araghchi addressed the “complex challenges” facing Syria and the broader region in a recent discussion, a recent report said. The report reflects the importance that Iran places on trying to find a way back to Damascus after the fall of the Assad regime.

Israel has paved the way for a decisive strike against Iran’s nuclear programme by eliminating swathes of Syria’s military infrastructure, according to officials speaking to The Telegraph following the fall of Bashar al-Assad’s regime.

Iran's Supreme Leader Ayatollah Ali Khamenei said on Wednesday that the toppling of Syrian President Bashar al-Assad was the result of a plan by the United States and Israel.