Greenville is a city in and the county seat of Greenville County, South Carolina, United States. With a population of 70,720 at the 2020 cens…Greenville is a city in and the county seat of Greenville County, South Carolina, United States. With a population of 70,720 at the 2020 census, it is the sixth-most populous city in the state. The Greenville metropolitan area had 928,195 residents in 2020 and is the largest metro area in South Carolina. Greenville is the anchor city of Upstate South Carolina, an economic and cultural region with an estimated population of 1.59 million as of 2023.
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