Milo is a village in Vernon County, Missouri, United States. The population was 90 at the 2010 census. Milo was laid out by J.L. Samples on October 4, 1881 when the Lexington and Southern Railroad division of the Missouri Pacific Railroad, located in the northwest part of Drywood Township; created a station nearby. The community name has been tied to Milo…Milo is a village in Vernon County, Missouri, United States. The population was 90 at the 2010 census. Milo was laid out by J.L. Samples on October 4, 1881 when the Lexington and Southern Railroad division of the Missouri Pacific Railroad, located in the northwest part of Drywood Township; created a station nearby. The community name has been tied to Milo, Maine and an early settler named Milo Main. A post office has been in operation at Milo since 1883.