Harrisville is a city in the U.S. state of Michigan and the county seat of Alcona County. The population was 437 at the 2020 census, making …Harrisville is a city in the U.S. state of Michigan and the county seat of Alcona County. The population was 437 at the 2020 census, making Harrisville the sixth-smallest city by population in the state of Michigan. The city is surrounded by Harrisville Township but is administratively autonomous. Located on Lake Huron, it is an official Michigan Department of Natural Resources Harbor of Refuge.