New Look at RSV Infection: Tissue Clearing and 3D Imaging of the …
WEBJan 28, 2021 · Methods: By combining tissue clearing, 3D microscopy and image processing, we developed a novel visualization tool of RSV infection in undissected mouse lungs. Results: Whole tissue analysis allowed the identification of infected cell subtypes, based on both morphological traits and position within the cellular network.
New Look at RSV Infection: Tissue Clearing and 3D Imaging of
WEBJan 28, 2021 · Whole lung clearing and 3D deep imaging represents an unprecedented visualization method of infected lungs to allow insight into RSV pathophysiology and improve the 2D histology analyses.
Respiratory syncytial virus entry and how to block it
WEBFeb 5, 2019 · Respiratory syncytial virus (RSV) is a leading cause of lower respiratory tract disease in young children and elderly people. Although the virus was isolated in 1955, an effective RSV...
The Morphology and Assembly of Respiratory Syncytial Virus …
WEBAug 20, 2018 · RSV is a pleomorphic enveloped RNA virus in the Pneumoviridae family. Recently, the three-dimensional (3D) structure of purified RSV particles has been elucidated, revealing three distinct morphological categories: spherical, asymmetric, and …
Three-Dimensional Cell Culture Models to Study Respiratory Virus ...
WEBDec 25, 2021 · A549 cells were grown as monolayers in 75 cm 2 plastic tissue-culture flask (left) and as spheroids using ultra-low attachment (ULA) plates to test A549 Spheroid’s permissiveness to Respiratory Syncytial Virus (RSV).
The Morphology and Assembly of Respiratory Syncytial Virus
WEBAug 20, 2018 · RSV is a pleomorphic enveloped RNA virus in the Pneumoviridae family. Recently, the three-dimensional (3D) structure of purified RSV particles has been elucidated, revealing three distinct morphological categories: spherical, asymmetric, and …
New look at RSV infection : tissue clearing and 3D imaging of …
WEBDec 23, 2020 · Furthermore, 3D imaging was also valuable to detect the cytoplasmic viral factories, also called inclusion bodies, a hallmark of RSV infection. Conclusions Whole lung clearing and 3D deep-imaging represents an unprecedented visualization method of infected lungs to allow insight into RSV pathophysiology and …
Cryo-EM structure of the nucleocapsid-like assembly of respiratory ...
WEBAug 22, 2023 · Respiratory syncytial virus (RSV) is a nonsegmented, negative strand RNA virus that has caused severe lower respiratory tract infections of high mortality rates in infants and the elderly,...
IGF1R is an entry receptor for respiratory syncytial virus
WEBJun 3, 2020 · Respiratory syncytial virus enters cells by binding to cell-surface IGFR1, which activates PKCζ and induces trafficking of the NCL coreceptor to the RSV particles at the cell surface.
3D engineered tissue models for studying human-specific …
WEBMar 1, 2023 · In this review, we summarized the recent advances in 3D engineered tissue models that mimic organ-specific viral infections. First, we briefly described the limitations of the current 2D and animal models in recapitulating …
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