African Horse Sickness - MSD Veterinary Manual
WEBLive-attenuated vaccines are commercially available, and these are typically based on cell culture–attenuated viruses and generally provide good, but not absolute, protection. Annual revaccination is recommended in regions where these vaccines are used.
African Horse Sickness: A Review of Current Understanding and Vaccine …
WEBSep 11, 2019 · Live attenuated vaccines (LAV) have been used with relative success for many decades but carry the risk of reversion to virulence and/or genetic re-assortment between outbreak and vaccine strains. Furthermore, the vaccines lack DIVA capacity, the ability to distinguish between vaccine-induced immunity and …
African Horse Sickness: A Review of Current Understanding and Vaccine …
WEBSep 11, 2019 · African horse sickness is a lethal and debilitating disease of domestic equids. There is little doubt that the live attenuated vaccine that has been used in South Africa to protect horses against AHSV for the past six decades [160, 161] has ensured their continued existence.
African Horse Sickness Caused by Genome Reassortment and …
WEBOur analysis confirmed that individual outbreaks were caused by virulent revertants of AHSV type 1 live, attenuated vaccine (LAV) and reassortants with genome segments derived from AHSV types 1, 3, and 4 from a LAV used in South Africa.
Safety and immunogenicity of plant-produced African horse …
WEBOct 11, 2018 · Immunization with live attenuated vaccines (LAVs) [3] has been the primary control strategy to date, but recent research has shown that vaccines of this nature carry the inherent risk of reverting to virulence, as well as the possibility of gene segment re-assortment between outbreak and vaccine strains [4].
Development of Differentiating Infected from Vaccinated Animals …
WEBLive attenuated vaccines (LAV), which provide broad protection against all 9 AHSV serotypes, are produced by Onderstepoort Biologic Products (OBP; https://www.obpvaccines.co.za) and are commercially available.
Safety and efficacy of inactivated African horse sickness (AHS) vaccine …
WEBOct 21, 2020 · Vaccination against insect-borne diseases such as AHS is the most effective control measure. Multivalent cocktails of live-attenuated vaccines (LAVs) for AHSV serotypes are commercially available and applied in Africa [24], [5].
Reverse genetics approaches: a novel strategy for African horse ...
WEBAHSV is endemic in sub-Saharan Africa, where polyvalent live attenuated vaccine is in use even though it is associated with safety risks. This review article summarizes and compares new strategies to generate safe and effective AHSV vaccines based on protein, virus like particles, viral vectors and reverse genetics technology.
Volume 22, Number 12—December 2016 - Centers for Disease …
WEBOur analysis confirmed that individual outbreaks were caused by virulent revertants of AHSV type 1 live, attenuated vaccine (LAV) and reassortants with genome segments derived from AHSV types 1, 3, and 4 from a LAV used in South Africa.
Safety and efficacy of inactivated African horse sickness (AHS) vaccine …
WEBOct 21, 2020 · Live-attenuated vaccines (LAVs) are licensed, marketed and in use in Africa. Their application is controversial with regard to safety issues. LAVs are not allowed in AHS-free countries. We here studied inactivated AHSV with different adjuvants in guinea pigs and horses. Subcutaneous and intramuscular vaccination were studied in horses.
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